PRE-CONFERENCE SHORT COURSES* | TUESDAY, SEPTEMBER 25 | 2:00 - 5:00 PM
This course will provide an understanding for some of the pharmacological complexities of G protein-coupled receptors (GPCRs) as well as for the tools used to study them in a drug discovery setting. The course is well suited for biologists, pharmacologists
and medicinal chemists who have recently started working with GPCRs or for those who need a refresher on the latest technological advances and newest paradigms.
Instructor: Annette Gilchrist, PhD, Professor, Pharmacology, Midwestern University
PRE-CONFERENCE DINNER SHORT COURSES* | TUESDAY, SEPTEMBER 25 | 6:00 - 8:30 PM
The course will present a progression from small animal models (Galleria, mice) to more elaborate biofilm models (mice, rats, rabbits), and conclude with larger complicated models that include trauma reflective of where these infections cause hardware
and implant problems (rats, pigs, goats). Each instructor will present typical evaluations of antibacterial products, both successes and failures. Each instructor will present examples of traditional small molecule antibiotic successes/controls and
compare them to alternative antibacterial treatments such as vaccines, bacteriophage, etc. Important considerations for model development will be addressed such as: strain selection, biofilm, method of delivery, dosing, PK/PD considerations.
Instructors: Daniel V. Zurawski, PhD, Scientist/Principal Investigator, Walter Reed Army Institute of Research
Joseph C. Wenke, PhD, U.S. Army Institute of Surgical Research
Kamilia Abdelraouf, PhD, Associate Director, Center for Anti-Infective Research and Development, Hartford Hospital
DINNER SHORT COURSES* | THURSDAY, SEPTEMBER 27 | 7:00 - 9:30 PM
Our lack of understanding of the molecular basis for compound penetration into and efflux out of gram-negative bacteria has been identified as a key bottleneck for the rational discovery of novel antibacterial compounds. A main driver of this knowledge
gap is the historical lack of assays, tools, and/or predictive models to provide medicinal chemists with structure-activity relationships that could guide optimization of whole cell penetration (and efflux avoidance). However, there have been
some recent, promising advances in the field which set the stage for future innovative approaches.
Instructors: David Six, PhD, Investigator III, Infectious Diseases, Novartis Institutes for BioMedical Research
Ram Iyer, PhD, Principal Scientist (Bacteriology), Entasis Therapeutics, Inc.
See the rest of the short courses here: DiscoveryOnTarget.com/Short-Courses
* Separate registration required